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Post-doctoral position at University of Lille (North of France) with LASIR

jeudi 7 février 2019

Subject of the PhD thesis : Developing dosimetry tools with Electron Paramagnetic Resonance spectroscopy (EPR) and chemometrics in the framework of radiological accidents or malevolent acts.

Duration : 3 years

Starting date : free to begin between September and December 2019

Localization : University of Lille (North of France).

PhD advisors : Ludovic Duponchel (LASIR Lab) and François Trompier (IRSN).

Abstract :

This research is part of a continuous collaboration between the LASIR Lab at the University of Lille and The French Institute for Radiological Protection and Reactor Safety (IRSN). The three years thesis work will be focused on the development of new chemometric tools for the exploration of Electron Paramagnetic Resonance spectra in the framework of dosimetry. More precisely we will try to quantify radicals from human biological specimens (bones, nails, tooth enamel…) in order to identify individuals exposed to ionizing radiation and determine the received exposure doses during radiological accidents or malevolent acts. It is obvious that no radioactive materials will be manipulated during the thesis. Indeed potential exposure of materials will observed through the presence of radicals in harmless inert samples.

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Subject of the PhD thesis : Developing dosimetry tools with Electron Paramagnetic Resonance spectroscopy (EPR) and chemometrics in the framework of radiological accidents or malevolent acts.

Duration : 3 years

Starting date : free to begin between September and December 2019

Localization : University of Lille (North of France).

PhD advisors : Ludovic Duponchel (LASIR Lab) and François Trompier (IRSN).

Abstract :

This research is part of a continuous collaboration between the LASIR Lab at the University of Lille and The French Institute for Radiological Protection and Reactor Safety (IRSN). The three years thesis work will be focused on the development of new chemometric tools for the exploration of Electron Paramagnetic Resonance spectra in the framework of dosimetry. More precisely we will try to quantify radicals from human biological specimens (bones, nails, tooth enamel…) in order to identify individuals exposed to ionizing radiation and determine the received exposure doses during radiological accidents or malevolent acts. It is obvious that no radioactive materials will be manipulated during the thesis. Indeed potential exposure of materials will observed through the presence of radicals in harmless inert samples.

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Postdoctoral position in physical chemistry to study iron-sulfur protein systems at IBS Grenoble

vendredi 18 janvier 2019

Postdoctoral position in physical chemistry to study iron-sulfur protein systems

The IBS/Metalloproteins and SyMMES groups - part of joint laboratories at University Grenoble Alps (UGA)/ French National Center for Scientific Research (CNRS)/ French Alternative Energies and Atomic Energy Commission (CEA), Grenoble, France - are looking for a postdoctoral researcher for a project to characterize the reactive intermediates of iron-sulfur proteins involved in antibiotic synthesis. Several advanced EPR methods, including pulsed multifrequency EPR, will be used in combination with other methods (biochemistry) and DFT simulations. The work will involve relatively simple sample preparation – at IBS – and extensive analysis by spectroscopic techniques, which will be carried out at SyMMES. The two laboratories are located on the same scientific campus in Grenoble, France, have a long history of collaboration, and are very well known in their respective fields of research :

Sicoli et al., Science, 2016, 351, 1320
Amara et al., JACS, 2018, 140, 16661

Qualifications
We are looking for outstanding candidates with a strong background in EPR spectroscopy. The candidate should hold a Ph.D. degree in chemistry or physics and have documented experience in demanding EPR spectroscopy experiments. Experience in DFT calculation and protein biochemistry would be a bonus.
Position Summary
Funding for this position has been awarded by the French National Research Agency (ANR). The position can be filled immediately, the initial contract will run for one year, with the possibility of extending funding for a second year. The salary will depend on experience, with a net starting rate of pay of about €2200 /month. Health insurance and social contributions will be paid by the employer.

About Grenoble
Grenoble is a major university town in France with more than 58,000 students from more than 70 different countries and a unique combination of a major University, several state-owned basic- and applied-research organisations, high ranking international scientific facilities (ESRF synchrotron facilities and ILL neutron facilities) and major high-tech industries. Thanks to this diversity, Grenoble is a hive of activity at all hours of the day and night ! Grenoble is also well known for its unique position in the French Alps with major ski resorts accessible in under an hour, and exceptional natural sites to visit in other seasons.

Applications
Candidates should contact Serge Gambarelli, +33438783940
with :
• Cover letter (max. one page)
• CV
• PhD degree
• Transcript of academic records
• Letters of recommendation or contact details for potential referees
The deadline for applications is 15 April 2019, but the position will remain open until filled.

PDF - 217 ko
postdoctoral_researcher_ibs_2019.pdf


Post-doctoral position at CReS (Total/MS) with LASIR

jeudi 19 juillet 2018

11 juillet 2018

Chemical science

Applications of EPR techniques in studying the stability of base oils and formulated lubricants

Understanding the factors that impact ageing is key to develop new products with high added values and long term stability. One of the priorities for the MS R&D is to develop products with low ageing properties and high durability. Today’s engine lubricant must comply with manufacturers specifications that are more and more restrictive. The lubricant needs to be formulated to resist longer constrains linked to more and more compact and powerful engines. As a result, it is important for the formulation to comply with manufacturer specifications which rely on Fuel Economy and Durability.

Lubricant stability study can be divided into different steps : base oil stability, additive package stability and formulated lubricant stability. All of these events potentially involve single electron transfers that can be characterized by Electron Paramagnetic Resonance (EPR) spectroscopy with or without the use of spin straps to stabilize the radicals.

EPR technique is highly sensitive and can be easily applied, in the conventional continuous wave, CW, mode, to identify and quantify radicals in a petroleum product. Unlike most other analytical techniques, EPR spectroscopy enables the study of the early stages of the ageing process and allow to gain a deeper understanding on the precursors involved. Besides, pulsed EPR can also be used to get access to the chemical environment of the electron in order to better describe the structure of the active site. The other asset of pulsed EPR is that measurements are performed at low temperature which allow to study processes which are slowed down at 4K and cannot be studied at room temperature.

The objectives of this post-doctoral internship are as follow :

  • Understand the ageing process of base oils depending on the group of origin : identify and quantify the different radicals present using spin traps and a computation approach such as DFT
  • Screen base/additives couples in order to identify the best chemistries for anti-oxidants : assess the impact of an additive or an additive package on the formation of radicals in base oils
  • Understand the stability of performance additives containing paramagnetic centers such as molybdenum : using pure additive or additive package, assess the structural and/or oxidation state changes of paramagnetic centers depending on the ageing process used
  • Predict the stability of a base or a formulated lubricant depending on the ageing process involved : establish paramagnetic or radical markers that can be used to predict the stability of a formulated lubricant

This internship, in partnership with LASIR (Hervé Vezin’s group), will be mostly localized in Lyon for the use of CW EPR EMX-nano. Stays in Lille will also be scheduled when pulsed EPR is required.

Keywords : EPR, lubricant, base oil, pulsed EPR, spin traps

Academic supervisor Dr. Hervé Vezin : laboratoire de Spectrochimie Infrarouge et Raman (LASIR) Lille

TOTAL supervisor Dr. Simon Pondaven : responsable du laboratoire de RMN et RPE, Département Analyse Physico-chimique, CReS, Lyon

Duration and start date 12 months

Employer CNRS

Academic requirements Ph.D. in EPR, knowledge of CW and pulsed EPR, use of Spin trap

Language requirements Fluency in French and/or English

PDF - 284.9 ko
post-doctoral_position_at_cres_total-ms_with_lasir.pdf


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